A drugs boss and five key aides were arested in the timed raids by forces from Serbia and Spain.
The Serbia-led operation involved authorities from Brazil, Croatia, France, Poland, Spain, and Slovenia.
The drug cartel was involved in the wholesale trafficking from South America to Europe.
The multiple law enforcement activities against the network was co-ordinated by Europol.
Six people were arrested and 15 houses searched.
Other seizures include: two high-end vehicles, luxury watches and more than €550, 000 in cash.
Many bank accounts and real estates have been blocked for the duration of the on-going financial investigation.
A Europol spokesperson said:
“Operational intelligence pointed out that the skippers from Ukrainian and Czech nationality travelled several times to Capo Verde or other locations in West Africa to prepare their vessel for smuggling operations.
“Information revealed that the vessel was in Brazil.
“This enabled Brazilian and Spanish authorities, to closely watch its movements.
“Investigators identified a Serbian national as one of the main organisers in the criminal network, who was then designated to be a High Value Target (HVT).
“The law enforcement actions targeted this Serbian HVT, as well as other individuals instrumental for the continuous functioning of the drug cartel’s operations.
“These main co-ordinators of the drug cartel arranged the shipping operations via encrypted communication platforms.”
Europol eased the exchange of information and supplied continuous analytical support to the investigation.
The intelligence development revealed a complete covered network running across continents and countries.
The takedown of three encrypted communication tools used by criminals, namely Encrochat, Sky ECC and Anom, has given international law enforcement an unprecedented insight into criminal networks and how they function.
